Departmental homepageComing from a background in philosophy and cognitive science at the University of Oxford, Dr Luppi obtained his PhD in neuroscience from the University of Cambridge and the Alan Turing Institute. After postdoctoral training in Neuro-Engineering at the Montreal Neurological Institute, he is now back in Cambridge as a Wellcome Early Career Fellow. His work combines network science and information theory to look at the interactions between brain regions, how they support computation and how they change when consciousness is lost.
Dr Luppi investigates the dynamics and connectivity of the brain. He combines tools from information theory, network science and whole-brain computational modelling to understand how different brain perturbations (anaesthesia, stimulation, injury) can suppress or restore consciousness. At the intersection of integrative and computational neuroscience, Dr Luppi's work spans multiple species (humans, non-human primates, mice) and modalities (functional MRI, diffusion tractography, PET, genetics). Through these different lenses, the ultimate goal is to map the cognitive architecture of the human brain.
Luppi, A. I., Singleton, S. P., Hansen, Jamison, K., J. Y., Bzdok, D., Kuceyeski, A., Betzel, R. F., & Misic, B. (2024) Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies. Nature Biomedical Engineering.
Luppi, A. I., Mediano, P. A., Rosas, F. E., Holland, N., Fryer, T. D., O’Brien, J. T., ... & Stamatakis, E. A. (2022) A synergistic core for human brain evolution and cognition. Nature Neuroscience, 25(6), 771-782.
Luppi, A. I., Hansen, J. Y., Adapa ... Misic, B., & Stamatakis, E. A. (2023) In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape. Science Advances.
Luppi, A. I., Rosas, F. E., Mediano, P. A., Demertzi, A., Menon, D. K., & Stamatakis, E. A. (2024) Unravelling consciousness and brain function through the lens of time, space, and information. Trends in Neurosciences.
